The article below may contain offensive and/or incorrect content.
Objective: The present study aimed to comprehensively study the specific neurocognitive constructs underlying verbal memory deficits and their neuroanatomical correlates in first episode psychosis (FEP) patients. Method: A total of 218 FEP patients and 145 healthy participants were examined with the Rey Auditory Verbal Learning Test (a widely used verbal memory measure that provides a range of performance indexes to evaluate memory) and voxel-based morphometry (a neuroimaging analysis technique that allows investigation of focal differences in brain anatomy). Results: The analyses showed that the FEP group presented significantly lower scores on acquisition/learning, F(1, 566) = 40.7; p < .001, and delayed recall, F(1, 570) = 74.12; p < .001, as well as higher rates of forgetting, F(1, 566) = 20.03; p < .001. They also exhibited a significant sensitivity to retroactive, F(1, 554) = 8.74; p = .003, but not to proactive interference. Neuroimaging analyses found significant interactions between bilateral frontal lobe morphometry and proactive interference (ρFWE = 0.023). Rate of forgetting also significantly interacted with right occipital cortex morphometry (ρFWE = 0.033). Patients with higher rates of forgetting, proactive and retroactive interference demonstrated further gray matter reductions in frontal and occipital cortical areas. Conclusions: These findings emphasize the anterior orbitofrontal cortex as the brain region that contributes to verbal memory deficits in FEP patients, and suggest specific relationships between different neuroanatomical structures and discrete verbal memory processes. (PsycINFO Database Record (c) 2019 APA, all rights reserved)





Parent Site

Departments
Authors
Libraries
Current Articles
- Article Correctness Is Author's Responsibility: Video » NIMH Expert Dr. Krystal Lewis Discusses Managing Stress & Anxiety
- Article Correctness Is Author's Responsibility: Scientific Meeting » NIMH Livestream Event: Managing Stress and Anxiety
- Article Correctness Is Author's Responsibility: A third of Americans don't see systemic racism as a barrier to good health
- Article Correctness Is Author's Responsibility: What brain imaging tells us about decluttering our minds
- Article Correctness Is Author's Responsibility: Blog Post » Showing Support for Basic Researchers
- Article Correctness Is Author's Responsibility: How to reduce news-related stress for better mental health
- Article Correctness Is Author's Responsibility: Five myths about loneliness
- Article Correctness Is Author's Responsibility: How to help someone struggling with suicidal ideation
- Article Correctness Is Author's Responsibility: Better sleep hygiene is crucial when you're anxious
- Article Correctness Is Author's Responsibility: How to remotivate kids for more distance learning
- Article Correctness Is Author's Responsibility: How to set goals you’ll actually achieve
- Article Correctness Is Author's Responsibility: To 'keep sharp' this year, keep learning
- Article Correctness Is Author's Responsibility: Mental health is one of the biggest issues facing 2021
- Article Correctness Is Author's Responsibility: Reasons to prioritize better sleep in 2021
- Article Correctness Is Author's Responsibility: Coping with post-holiday blues amid coronavirus
- Article Correctness Is Author's Responsibility: Video » The NIMH Director’s Innovation Speaker Series: Pursuing an Innovation Agenda: A New Healthcare Architecture
- Article Correctness Is Author's Responsibility: Pandemic worsening domestic abuse
- Article Correctness Is Author's Responsibility: Young people's anxiety levels nearly doubled during first Covid-19 lockdown
- Article Correctness Is Author's Responsibility: Video » NIMH Director’s Innovation Speaker Series: Decision-Making and Computational Psychiatry
- Article Correctness Is Author's Responsibility: Blog Post » The Lives Lost to COVID-19